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Tay-Sachs disease) Causes: (a) Microvesicular: Aspirin (Reye's syndrome), ketoprofen, tetracycline (b) Macrovesicular: Acetamenophen, methotrexate (c) Phospholipidosis: Amiodarone, total parenteral nutrition Granuloma: Drug induced hepatic granulomas are usually associated with granulomas in other tissues and patients typically have features of systemic vasculitis and hypersensitivity

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When drugs are fast released into the body they may produce severe adverse reactions because their plasmatic concentration may reach high values in a very short time

It finds the problem