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It is also important to note that early-phase trials such as those conducted for retatrutide typically exclude participants with active major depressive disorder or suicidal ideation, which may limit the detection of psychiatric adverse events in the published data

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Medical concepts are systematically categorized using the Medical Dictionary for Regulatory Activities (MedDRA) terminology, with Preferred Terms (PTs) representing granular AE descriptions, hierarchically grouped into High-Level Terms (HLTs), High-Level Group Terms (HLGTs), and System Organ Classes (SOCs) 18,19