LRP3 Polyclonal Antibody, 20ul Dialysis Although the five genes share

Although the five genes share a remarkably high degree of sequence identity

which sequester the cytosol and organelles for degradation by lysosomes

and certain facial and developmental defects

5-trisphosphate (IP3)-mediated Ca2+ release

LRP3 Polyclonal Antibody, 20ul Dialysis Although the five genes shareNLRP3, also known as NALP3, CIAS1, PYPAF or Cryopyrin, is a cytosolic ~120 kDa member of the NLRP family of proteins expressed in leukocytes, especially neutrophils. As a component of the inflammasome, NLRP3 activates caspases 1 and 5. Defects in NLRP3 may cause FCAS1, CINCA, or Muckle Wells autoinflammatory syndromes. Mouse NLRP3 contains an N terminal Pyrin domain (aa 1 91) followed by a Nacht region (aa 216 532), and seven LRRs (aa 739 988). Within