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P.g and its metabolites directly and indirectly compromise gut integrity by downregulating the expression of tight junction proteins (ZO-1, Occludin, Claudins) and mucins (MUC2), leading to increased intestinal permeability (Tsuzuno et al., 2021

But if you're on a GLP-1 medication Ozempic, Wegovy, Mounjaro, Zepbound, Trulicity, or any of the others that have become part of daily life for so many Canadian s you already know that your medication comes with a few extra considerations

2017 Cell study (PMID: 28340339) used 5 mg/kg body weight administered via intraperitoneal injection three times per week

Second, genetic variation in GLP1R expression and function means that some individuals experience maximal appetite suppression at lower doses, rendering further escalation unnecessary and potentially counterproductive