MAGI-2 Polyclonal Antibody, 50ul DNA Synthesis designated the Sec insertion sequence

designated the Sec insertion sequence (SECIS) element

suggesting that down-regulation is the result of methylation of the gene

Mutations in GNPAT are associated with rhizomelic chondrodysplasia punctata

The protein encoded by this gene is a DNA helicase that belongs to the RecQ helicase family

MAGI-2 Polyclonal Antibody, 50ul DNA Synthesis designated the Sec insertion sequenceThe protein encoded by MAGI2 (membrane associated guanylate kinase, WW and PDZ domain containing 2)interacts with atrophin 1. Atrophin 1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase like domain, and multiple PDZ domains. It has structural similarity to the membrane associated guanylate kinase homologue (MAGUK)