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Using liver homogenates as the enzyme source, activity of cytochrome P450 in the rat was higher in the median and right lobes of the liver, and mitochondrial enzymes were higher in the left lobe (Matsubara et al

The authors are also thankful for the financial support provided by the National Counsel for Technological and Scientific Development (CNPQ) Brazil

Although there are no clear doseeffect data, a threshold exists for the development of alcoholic hepatitis, with risk increasing with consumption beyond 40 g of alcohol per day