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This brief duration of action is why pharmaceutical companies developed longer-acting GLP-1 receptor agonists for therapeutic use

L.QiuF.et al (2024b)

Seo KS, Cloyd JD

While GLP-1 suppresses appetite and slows gastric emptying, GIP enhances insulin secretion and possibly changes how the body uses fat, and glucagon increases energy expenditure and promotes fat breakdown