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More than three in four patients lost more than 5% of their baseline weight, and more than one in three patients lost more than 10%

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You should contact your GP or diabetes care team if you experience: Severe or persistent gastrointestinal symptoms , particularly if you have: Severe abdominal pain that does not improve Persistent vomiting that prevents you from keeping down food or fluids Signs of dehydration (dark urine, reduced urine output, dizziness, dry mouth) Symptoms suggestive of pancreatitis (severe, persistent abdominal pain radiating to the back, often accompanied by nausea and vomiting) Signs of gallbladder disease , including: Pain in the right upper abdomen Fever Yellowing of the skin or eyes (jaundice) Significant mood changes or mental health concerns , including: Persistent low mood, anxiety, or depression Mood swings that interfere with daily activities or relationships Thoughts of self-harm (seek urgent help via your GP, NHS 111, or emergency services) Recurrent hypoglycaemia , especially if you experience frequent episodes of low blood sugar or are unaware of warning symptoms