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Endogenous GLP-1 is rapidly degraded primarily by dipeptidyl peptidase-4 (DPP-4), as well as neutral endopeptidase 24.11 (NEP 24.11) and renal clearance, resulting in a half-life of approximately 2 minutes

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Subsequently, a comprehensive review of the full texts was conducted The study selection process was documented in accordance with the PRISMA 2020 guidelines (Page et al