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GPX4 activators have shown promise in halting ferroptosis in preclinical studies

Since most reactions in the second stage are spontaneous, tyrosinase acts as the rate-limiting enzyme in melanin synthesis, making it the primary enzyme involved in both enzymatic browning and melanin production 7

Thus, the main analytical sample included 2574 participants (2363 from NESDA baseline and 211 siblings) with data on MDD diagnostic status, overall depression severity, and depressive symptoms profiles and at least one of the investigated metabolites