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Registered dietitians working with GLP-1 patients consistently flag protein as the first thing to prioritize, precisely because a smaller appetite makes it hard to reach a target through whole food alone

For example, GLP-1RAs may modulate the CD36-JNK-AP1 pathway by partially down-regulating prolyl 4-hydroxylase subunit alpha-1 (P4HA1), and then inhibit ROS production mediated by Ang II type I receptor, thereby ameliorating cardiac fibroblast proliferation and myocardial fibrosis [167, 168]

It can be used in people with obesity (with a body mass index, or BMI, of 30 or higher)

Adding 30 minutes of moderate activity per day can amplify the effect by another 0.5 to 1 pound during the first week