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1 Introduction Nanomedicine has emerged as a promising field in biomedicine over the past few decades, owing to the exceptional pharmacokinetics and high-contrast imaging capabilities of nanotherapeutics and diagnostic agents ( Numerous strategies have been devised and implemented to alleviate the influence of MPS ( in vivo , surpassing the RES threshold and penetrating the immune barrier, thereby prolonging the circulation time of blood and facilitating accumulation in tumors ( The strategy of eliminating macrophages to obstruct the mononuclear phagocyte system (MPS) has attracted significant attention

Expert Rev Clin Immunol 10:15191530 Coates LC, Merola JF, Grieb SM, Mease PJ, Duffin KC (2020) Methotrexate in psoriasis and psoriatic arthritis

At the same time, as the quality of life of patients improves, their psychological state will also be improved, and they will cooperate more actively with treatment to enhance treatment effectiveness

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