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The patient developed rapid heart and respiratory rates, headaches, and night blindness, and ultimately became comatose

Fortunately, this is not the typical experience for most patients

Individuals with kidney disease should exercise particular caution with magnesium supplementation, as impaired kidney function can affect magnesium clearance

A sample size of 54 subjects (14 normal renal function and ten in each of the four RI groups) was calculated to be sufficient for the primary objective of the study, with a power of 82% to show equivalence of exposure between subjects with severe RI and subjects with normal renal function