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Seek immediate medical evaluation if swollen lymph nodes are accompanied by: Systemic symptoms : Unexplained fever, drenching night sweats, or unintentional weight loss (beyond expected tirzepatide-related weight reduction) Rapid enlargement : Lymph nodes that grow quickly over days to weeks Hard, fixed, or irregular nodes : Lymph nodes that feel firm, immobile, or matted together Size : Nodes larger than 1-2 cm (approximately half an inch to one inch) that persist beyond two weeks Location : Supraclavicular (above the collarbone) lymphadenopathy, which has higher association with serious pathology Associated symptoms : Difficulty breathing, swallowing, or persistent cough