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However, in the context of rapid economic growth, many historical areas are subjected to transformations driven by urban renewal, resulting in the erosion of historical continuity.Pezzetti,2019The fragmentation of historical traces in these cities has led to the loss of systematic readability, while the reconstruction of meaning for key historical sites has often been limited to superficial forms of individual buildings along prominent historical axes, with less consideration for the larger spatial organization that once supported urban life.Pezzetti and Liu,2019 Xi'an, as a representative example of historical cities, illustrates how architectural relics, embedded within the broader urban fabric, contribute to the value of individual buildings.( Miu,1990) This study focuses on the evolution of historical spaces along three main axes within the citys structure

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Summary Keywords amodiaquine, quinoneimine, cytotoxicity, endoplasmic reticulum stress, human glutathione S -transferases P1 Citation Zhang Y, den Braver-Sewradj SP, den Braver MW, Hiemstra S, Vermeulen NPE, van de Water B, Commandeur JNM and Vos JC (2018) Glutathione S -Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells