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sirtinol - CAS# 410536-97-9 217 9(1):113-25

sirtinol - CAS# 410536-97-9 217 9(1):113-25

Name: sirtinol - CAS# 410536-97-9 217 9(1):113-25
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sirtinol - CAS# 410536-97-9 217 9(1):113-25Sirtinol, CAS No. 410536 97 9, is a SIRT inhibitor. Sirtinol significantly increased the acetylation of p53, which has been reported to be a target of SIRT1 2. Sirtinol significantly increased the G1 phase of the cell cycle. Product information CAS Number: 410536 97 9 Molecular Weight: 394. 47 Formula: C26H22N2O2 Synonym: Sirtinol 2 [(2 Hydroxynaphthalen 1 ylmethylene)amino] N (1 phenethyl)benzamide 2 {[(2 hydroxy 1 naphthyl)methylene]amino} N (1

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Description

9(1):113-25

BMC Cancer

Conkling PR

It binds to the enzyme active site and inhibits DNMT enzymatic activity with an IC50 ~ 115 nM

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