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The cited literature discusses cellular signaling, skin-model, and tissue-remodeling research

AS: Data curation, Funding acquisition, Investigation, Validation, Writing review & editing

Stronger mechanistic clarification would require isoform-specific NOS inhibition, direct measurement of NO metabolites, eNOS phosphorylation analysis, rescue experiments, and comparison across endothelial, epithelial, fibroblast, and neuronal model systems