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Rotenone increases glutamate-induced dopamine release but does not affect hydroxyl-free radical formation in rat striatum

In 2016, Imai expanded his hypothesis to NAD+ World Hypothesis 2.0, which postulates that NAMPT outside the cell (extracellular NAMPT) from fat tissue (adipose tissue) maintains NAD+ in the brains hormonal control center, the hypothalamus, to preserve skeletal muscle health against frailty during aging

However, given the superior CV benefits of GLP-1RAs, which differ somewhat from those attributed to SGLT2 inhibitors, we cardiologists also need to consider the CV benefits of GLP-1RAs and become more comfortable prescribing the agents for appropriate patients who may benefit the most from them

Posso-Osorio I, Vargas-Potes CJ, Meja M, et al