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Report leg swelling, chest pain, or sudden breathlessness immediately

Avoid repeated freeze-thaw cycles and keep materials in their original sealed container until ready for use

Crit Care Explor (2020) 2(10):e0272

31 CV Outcomes in Meta-Analyses of Phase 2 to 3 Trials With DPP-4 Inhibitors Several meta-analyses of RCTs with each of the DPP-4 inhibitor commercialized in the United States (vildagliptin is not available in the United States) and in Europe generally reported a nonsignificant trend toward a lower incidence of MACE compared with placebo or other active glucose-lowering compounds: alogliptin, 38 saxagliptin, 39 sitagliptin, 40 linagliptin, 41 and vildagliptin 42 (Table 1)