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Practitioners should follow appropriate infection control procedures and may wish to monitor injection sites more carefully in patients with diabetes, especially if glycaemic control is suboptimal

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We will enroll 300 AIS patients at up to 50 sites with baseline NIHSS 4, who can receive study drug within 4.5-24 hours of last known well (LKW), and with evidence of core-penumbra mismatch but not receiving standard of care acute stroke reperfusion therapies, will be eligible