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it is well absorbed by the intestine Metabolized by the liver, cysteine is one of metabolite It seems not to raise GSH levels if they are already within the normal range It can raise abnormally low GSH levels back to normal This is the basis for its use as an antidote to acetaminophen's liver toxicity Used in Europe for many years as a mucolytic agent 600 mg was beneficial and innocuous while 1200 mg and 1800 mg per day caused significant adverse effects Alpha lipoic acid Alpha lipoic acid (ALA) is available as supplement It is a natural antioxidants and could increase intracellular glutathione through it reducing power Selenium Is a co-factor for the enzyme glutathione peroxidase Studies suggest they may play a role in decreasing the risk of certain condition in which glutathione are depleted Too much selenium can cause toxic effects including gastrointestinal upset, brittle nails, hair lost and mild nerve damage Upper estimated requirement of 90 g Se/d Lower estimated requirement of 39 g Se/d Concluding remark Advances in molecular biology have led to an explosion of knowledge in understanding how the rate-limiting enzyme GCS is regulated at the molecular level, and prevention of complications that may result from altered GSH synthesis Protein (or amino acid) deficiency remains a significant nutritional problem in the world to day

Proc Natl Acad Sci USA 85 : 52745278 Di Chiara G, Tanda G