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Comment: A commenter raised a concern about the use of the term CHOW, believing that it only applies in situations where no TIN change occurs, citing the regulation at 42 CFR 489.18(c), which states: When there is a change of ownership as specified in paragraph (a) of this section, the existing provider agreement will automatically be assigned to the new owner. [403] Response: We appreciate this commenter's concern

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Discontinue if: Significant adverse reactions occur, you achieve body composition goals, no response after 8-12 weeks at optimal dosing, medical contraindications develop, or pregnancy occurs

For most research contexts, 9 mg therefore represents a more favourable efficacy-to-tolerability balance than 12 mg