TH588 - MTH1 Inhibitor. CAS# 1609960-31-7 stone Methyltransferase Discovery of Selective LRRK2 Inhibitors

Discovery of Selective LRRK2 Inhibitors Guided by Computational Analysis and Molecular Modeling

ADX47273 reduced rat-conditioned avoidance responding [minimal effective dose (MED) = 30 mg/kg i

Carboxylesterase 3 (Ces3

selective and cell permeable inhibitor of Jumonji domain-containing protein 2 (JMJD2) histone demethylase with IC50 ~0

TH588 - MTH1 Inhibitor. CAS# 1609960-31-7 stone Methyltransferase Discovery of Selective LRRK2 InhibitorsTH588, CAS No. 1609960 31 7, is a novel potent, selective and cell permeable inhibitor of the nudix hydrolase family MTH1 protein with an IC50 of ~5 nM. Protein co crystal structures demonstrate that TH588 binds in the active site of MTH1. It has excellent selectivity over other nudix family proteins and kinases present in the selectivity panel. The MTH1 protein sanitizes oxidized dNTP pools to prevent incorporation of damaged bases during DNA