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Steady weight loss typically begins within the first few weeks and continues over several months

V., Estrach, S., Feral, C

These include: Nausea Diarrhea Vomiting Constipation Stomach pain These side effects usually happen when you first start taking the drug and often go away after a few weeks as your body adjusts

In the SURMOUNT-1 trial, tirzepatide reduced systolic blood pressure by an average of 6.8 mmHg compared to placebo at 72 weeks, with about 68% of that change explained by weight loss