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On the other hand, individuals carrying ABCB4 variants that decrease MDR3 protein function have a more linear doseresponse curve, reflecting the functionality of MDR3 [88]

Published preclinical work often looks at cell migration, blood-vessel signalling, fibroblast activity, epithelial barrier models, and how local tissue environments respond under controlled conditions

over 50% of patients have persistent tinnitus, with a far higher incidence than carboplatin and oxaliplatin

Interestingly, a statistically significant association was found for 677TT genotype under the recessive model in the male patients subgroup, and CT genotype under the overdominant model in the total patients group 51