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Differentials Endometriosis Irritable bowel syndrome (IBS) Urinary tract infection More Differentials Guidelines Chronic pelvic pain Diagnosis and treatment of interstitial cystitis/bladder pain syndrome More Guidelines Log in or subscribe to access all of BMJ Best Practice Use of this content is subject to our disclaimer

Under oxidative stress and induced by excessive ROS generation, Nrf2 is released from its inhibitor Keap1, allowing its translocation into the nucleus (Kasprzak et al., 2020), where it binds to the antioxidant response element (ARE) present in the DNA sequence of numerous antioxidant enzymes like glutathione-S-transferase, -glutamyl cysteine synthetase (glutamate cysteine ligase), heme oxygenase 1, and paraoxonase-1 inducing their transcription, managing the phase II response to oxidative stress (Kasprzak et al., 2020)

doi:10.1002/jor.22831 [2] Park JR, Lee H, Kim SI, Yang SR

Biosensor Experiments The biosensor experiments were conducted as described earlier (Kugler et al., 2020)