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In accordance with the glutathione activator hypothesis, only positively charged amino acids replace Lys105 in enzymatically active glutaredoxins, whereas in inactive isoforms and other members of the thioredoxin superfamily the activator candidate is often separated from the catalytic cysteine residue in the primary sequence or is replaced by uncharged residues 3,11,12 (Fig

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10.1080/10715762.2018 10.1080/10715762.2018 [DOI] [PubMed] [Google Scholar] Halliwell B (2022) Reactive oxygen species (ROS), oxygen radicals and antioxidants: Where are we now, where is the field going and where should we go