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Trial SURMOUNT-1 Trial Phase 3 multicenter, double-blind, randomized, placebo-controlled trial was conducted at 119 sites in nine countries Intervention Participants were randomly assigned in a 1:1:1:1 ratio to receive tirzepatide at a dose of 5 mg, 10 mg, or 15 mg or placebo, administered subcutaneously once weekly for 72 weeks as an adjunct to lifestyle intervention

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continued 5.5% additional loss in tirzepatide continuation group SURMOUNT-4: Weight maintenance trial confirming sustained benefits over extended treatment [1] November 2023: FDA Approval for Obesity Zepbound (tirzepatide) approved for chronic weight management in adults with obesity (BMI 30) or overweight (BMI 27) with weight-related comorbidities