PRT4165 - E3 Ubiquitin-ligase Bmi1/Ring1A Inhibitor. CAS# 31083-55-3 30002 the binding site of NMS-873

the binding site of NMS-873 was found to be a region spanning the D1 and D2 domains of adjacent protomers encompassing elements important for nucleotide-state sensing and ATP hydrolysis

It has been shown to improve the reprogramming efficiency of mouse embryonic fibroblasts (MEFs) into induced pluripotent stem (iPS) cells

RN-1 can abolish long-term memory formation without affecting short-term memory in the novel object recognition (NOR) mouse model

and cell-permeable small-molecule agonist of the Hedgehog pathway

PRT4165 - E3 Ubiquitin-ligase Bmi1/Ring1A Inhibitor. CAS# 31083-55-3 30002 the binding site of NMS-873PRT4165, CAS No. 31083 55 3, is a small molecule inhibitor of polycomb repressive complex 1, which inhibits ubiquitin signaling at DNA double strand breaks. PRT4165 is a potent inhibitor of PRC1 mediated H2A ubiquitylation in vivo and in vitro. The drug also inhibits the accumulation of all detectable ubiquitin at sites of DNA double strand breaks (DSBs), the retention of several DNA damage response proteins in foci that form around DSBs, and the