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doi: 10.1146/annurev.micro.55.1.21 65 RitzD.PatelH.DoanB.ZhengM.AslundF.StorzG.et al

It may explain why some users report reduced "food noise" and cravings from Pendulum GLP-1 Probiotic Pro despite the modest nature of the GLP-1 increase

34 Consequently, turnover of 5,10-methyleneTHF via the TYMS enzyme is proposed to be greater in 3R3R individuals, with a decrease in this vitamer and an increase in homocysteine levels previously observed in such individuals