G-749 - CAS# 1457983-28-6 Catalog No.:M6514-10 A selective jumonji H3K27 demethylase

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response (2012) Nature

InChi: InChI=1S/C27H29FN2O3/c28-25-18-22(13-11-20(25)12-14-27(31)32)29-19-21-6-4-10-26-24(21)9-5-15-30(26)16-17-33-23-7-2-1-3-8-23/h1-4

6(10):e25134

and 10 (IC50 > 100 µM)

G-749 - CAS# 1457983-28-6 Catalog No.:M6514-10 A selective jumonji H3K27 demethylaseG 749, CAS No. 1457983 28 6, is a novel FLT3 inhibitor that showed potent and sustained inhibition of the FLT3 wild type and mutants including FLT3 ITD, FLT3 D835Y, FLT3 ITD N676D, and FLT3 ITD F691L in cellular assays. G 749 retained its inhibitory potency in various drug resistance milieus such as patient plasma, FLT3 ligand surge, and stromal protection. Furthermore, it displayed potent antileukemic activity in bone marrow blasts from AML patients