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TB-500 (Thymosin Beta-4): Mechanism, Evidence, and Clinical Application Thymosin beta-4 is a naturally occurring protein that aids in tissue repair all throughout the body, and TB-500 is a synthetic peptide generated from this protein

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Options for managing tolerance include a brief dose reduction for 4 to 8 weeks ("drug holiday" at a lower dose, not complete cessation), lifestyle optimization to maximize the medication effect, evaluation for other contributing factors (thyroid function, cortisol, sleep quality, medication interactions), and consideration of adding a complementary compound to address specific aspects of the plateau

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