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Beyond fat reduction, these medications may also impact connective tissue proteins like collagen and elastin, speeding visible skin aging

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J Med Genet 40:619625 Wilson A, Platt R, Wu Q, Leclerc D, Christensen B, Yang H, Gravel RA, Rozen R (1999) A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida