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Elevated cAMP acts mainly through the following molecular pathways: inhibition of the ERK pathway, activation of the PKA-AMPK-mTOR pathway, and activation of the p38 signaling pathway [13, 17, 5658]: first, it inhibits the extracellular signal-regulated kinase (ERK) pathway, decreasing its activation of cyclin D1, thereby hindering cyclin D1-mediated DNA replication initiation and transition into the S phase of the cell cycle [17]

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To view a copy of this license, visit About this article Cite this article Noh, J.Y., Yoon, SW., Kim, Y

The antiproteinuric effects of green tea extract on acute cyclosporine-induced nephrotoxicity in rats