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In the osteoblast igf-1 knockout using type I collagen Cre, IGF-1 expression was reduced fivefold in muscle ( igf-1 , displays a 59% reduction of IGF-1 mRNA levels in skeletal muscle, although gross muscle architecture appeared normal ( CONCLUDING REMARKS: TYING UP LOOSE ENDS IN THE IGF STORY Although an enormous volume of research spanning at least four decades has provided a substantial understanding of IGF-1 signaling and has even resulted in clinical interventions for growth impairment, much is yet to be learned with regards to its role in the maintenance of a healthy skeleton

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Treloar Padovano, H

Hammad, M