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Total T3 levels often decline during caloric restriction as the body downregulates metabolic rate to conserve energy, a process sometimes called "euthyroid sick syndrome" or "low T3 syndrome." Free T3 may remain in the normal range but trend toward the lower end

The animals receiving a combination of semaglutide and BI8271 had a significantly larger improvement in both tests compared with those receiving semaglutide monotherapy, suggesting that the extent of post-stroke recovery was positively correlated with the extent of pre-stroke body weight/glucose metabolism normalisation

Mice received once-daily sham injections with isotonic saline from 3 days before study start and were randomized to treatments on the basis of body weight at the day of study start