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High amounts of TILs are present in some TNBCs, which may indicate a better prognosis ( TME remodelling (attracting CD4+T cells, CD8+T cells, and NK cells) enhances the effectiveness of immunotherapy, an essential approach used to treat breast cancer, as TILs in the TME have a direct link to the prognosis of TNBC ( The blockade of the PD-1 pathway brings quiescent antitumor T cells to active life ( Figure 5 )

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doi: 10.1016/j.ajog.2018.12.011 14 BurchellA

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